Even though it can help many people, this medication includes a chance for abuse and will sometimes result in dependancy. This chance may very well be higher When you have a substance use problem (which include overuse of or habit to medicines/Alcoholic beverages).
Because of inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage, we no longer display the RxImage pill photographs affiliated with drug labels.
Retailer at area temperature away from mild and humidity. Will not shop in the toilet. Keep all drugs far from kids and Animals.
Also convey to your physician and pharmacist For those who have at any time had an strange or sudden reaction once you took promethazine, An additional phenothiazine, or every other medication. Ask your physician or pharmacist If you don't know if a medication you happen to be allergic to is really a phenothiazine.
By way of example, quite a few reported scenarios of Loss of life occurred in the article-operative interval adhering to tonsillectomy and/or adenoidectomy, and plenty of of the kids had evidence of being extremely-quick metabolizers of codeine. Furthermore, small children with obstructive snooze apnea that are addressed with codeine for article-tonsillectomy and/or adenoidectomy soreness may very well be specifically delicate to its respiratory depressant impact. As a result of risk of daily life-threatening respiratory melancholy and Dying:
It is soluble in water and freely soluble in alcohol. The molecular pounds is 320.88. Its molecular method is C17H20N2S•HCl, and it has the following chemical composition.
Severe, life-threatening, or fatal respiratory melancholy continues to be reported with using opioids, together with codeine, one of many Energetic ingredients in Promethazine with Codeine Oral Remedy. Codeine creates dose-related respiratory despair by straight performing to the Mind stem respiratory center that controls respiratory rhythm and could produce irregular and periodic respiration. Codeine is topic to variability in metabolism based mostly upon CYP2D6 genotype, which can result in an increased exposure into the Lively metabolite morphine [see Warnings and Precautions (5.three)]. Promethazine exerts a depressant impact on the respiratory center which is unbiased of and additive to that of other respiratory depressants, together with codeine [see Warnings and Precautions (five.
Assess each affected individual's danger ahead of prescribing Promethazine with Codeine Oral Remedy, prescribe Promethazine with Codeine Oral Remedy for the shortest period that's according to person client treatment method targets, keep an Promethazine codeine syrup eye on all people routinely for the development of addition or abuse, and refill only soon after reevaluation of the necessity for continued treatment. [see Warnings and Safety measures (5.1)]
The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are advanced, demanding cautious consideration of the effects over the dad or mum drug, codeine, as well as Lively metabolite, morphine.
Opioids can lessen the efficacy of diuretics by inducing the discharge of antidiuretic hormone. Monitor clients for indications of diminished diuresis and/or results on blood pressure and enhance the dosage of your diuretic as essential.
Codeine leads to a discount in motility affiliated with an increase in sleek muscle mass tone from the antrum on the belly and duodenum. Digestion of meals from the little intestine is delayed and propulsive contractions are lowered.
Talk to your health practitioner if you have any questions on getting codeine or regarding how this medicine might influence your baby.
Other Unwanted effects not shown may additionally arise in certain sufferers. If you see every other consequences, Check out together with your healthcare professional.
Endocrine/Metabolic: Cases of serotonin syndrome, a most likely lifetime-threatening issue, are actually claimed for the duration of concomitant utilization of opioids with serotonergic medications.